Officinal preparation of phosphoric acid.



JEAN NIGOLATDI, or PARIS, FRANCE.

OFFICINAL PREPARATION OF PHOSPHORIO ACID.

Specification of Letters Patent.

Patented March 2, 1909.

Application filed August 15, 1905. Serial No. 27 1325.

To all whom it may concern:

Be it known that I, JEAN NrcoLAinr, doctor of medicine, subject of theKing of Greece, residing at Paris, Department of the Seine, France, andhaving post-office address Rue de Miromesnil, in the said city, haveinvented certain new and useful Improvements in Manufacture andProduction of an Olhcinal Preparation of Phosphoric Acid, of which thefollowing is a specification.

This invention has for its object to roduce an officinal preparation offree p osphoric acid in a solid, and granulated, state.

The use of free phosphoric acid is at present largely advocated for thetreatment of certain diseases.

According to my invention I produce a preparation of phosphoric acid ina solid, and granulated, state, the whole of the said acid being in thefree state. The various preparations containing phosphates do not answerthe desired purpose as the phosphoric acid is combined with a base andconstitutes a salt such, for instance, as calcium phosphate, sodiumphosphate, and the like, and such salts are not suitable for use in thephosphoric acid treatment, they exerting an action on the patientdiffering entirely from that of free phosphoric acid.

It is essential that the product should be very stable whereasphosphoric acid itself is very hygroscopic and therefore liable tobecome soft and eventually to deliquesce.

According to my invention I provide a solid granular, and stable productcontaining phosphoric acid in a perfectly free state and not containinga trace of any matter capable of fixing, or chemically combining with,phosphoric acid and therefore the Whole of the phosphoric acid in theproduct remains in the free state. The said product is rapidly andcompletely soluble in water, the solution containing the whole of thephosphoric acid in the free state. The said product moreover can beconveniently and accurately dosed and is suitable for use by delicatepatients, who have difiiculty in assimilating phosphoric acid takenalone.

The product can be prepared as follows: Take a substance which does notcontain matter capable of chemically combining with phosphoric acid asmilk-sugar and treat it with pure phosphoric acid. Then add gum arabicor an equivalent substance not containing matter capable of chemicallycombining with phosphoric acid so as to give the mixture sufficientconsistency, and then from time to time a further quantity of the acidis added to render the mixture in proper condition for furthertreatment, as will now be explained. The paste thus obtained is thenmixed and kneaded for some time (say a few hours) in a mill made ofmaterial which will not be attacked by, or injure, or form a chemicalcompound, with, phosphoric acid. If the mill were made for instance ofiron, iron phosphates would be formed. The

aste may be colored by maceration with any armless substance capable ofcoloring it such for instance as Campeachy, or logwood.

The proportions of the several ingredients which give the best resultsare as follows: To 30 kilograms of milk sugar 4.050 kilograms ofphosphoric acid are added and suflicient gum arabic to render the massin a workable condition. The paste thus obtained is then granulated bymeans of a suitable apparatus which is also made of material which willnot be attacked by, or injure, or form compounds with, phosphoric acid.

The granulated product is collected on frames and dried in a dryingstove and then sifted and put into bottles, or other rece itacles, afterit has been ascertained by ana ysis that it contains the correct amountof free phosphoric acid.

Having thus described and ascertained the nature of my invention and inwhat manner the same may be performed, I declare that what I claim is:

The herein described process of obtaining an ofiicinal preparation ofphosphoric acid completely free of a basic salt or other substance,consisting in treating milk sugar with pure phosphoric acid, adding gumarabic to give the mixture suitable consistency, thoroughly kneadingthis product and adding further quantities of the pure phosphori cacidto keep the mass moist and to insure thorough permeation of the mass bythe acid, and finally drying and granulating the product.

In testimony whereof I have hereunto set my hand in presence of twosubscribing witnesses.

JEAN NICOLAIDI. Witnesses:

EMILE KLOTZ, MAX DE RIVAUD.

